Established in 2002, the Department of Computer Science and Engineering (CSE) is one of the two oldest departments of the university. The department's vision was to engender competent and skilled CSE graduates to avail and fill the lucrative job opportunities at that time. Since its establishment, the department has been offering a four-year undergraduate program titled Bachelor of Science in Computer Science and Engineering. From 2023, the department 23 also offers a two-year Master of Science in Computer Science and Engineering program. The courses of the undergraduate and graduate programs have a balance of theory and practical skills to prepare the learners for the highly competitive workplace. Apart from the degree awarding programs, the department has established three internationally affiliated academies, Cisco Networking Academy, AWS Academy, and Red Hat Academy to offer certification courses mainly to students and professionals.

In 2002, the DCSE of Premier University started its academic activities with 13 undergraduate students and two full-time faculty members. The average number of students admitted in the first semester was around 10 until 2012; from then, it started to rise dramatically, and at present, the recruitment average is above 200.

The department of CSE is supported by well-equipped and advanced labs including Artificial Intelligence Lab, Microprocessor-Microcontroller and IoT Lab, Software Development Lab, Operating System Lab, Computer Networking Lab, Lab, Competitive Programming Lab, Programming Labs and High-Performance Programming Lab. All these aims, visions, and missions are made a reality by the exceptional faculty members of the department through their friendly and effective collaboration. The department has successfully attracted highly competent and knowledgeable faculty members and researchers dedicated to offering the best available knowledge and experience to the students.

The Computer Club at Premier University, established in 2015, is a key strength of the CSE department, fostering a dynamic environment for students to engage in technology-driven activities. It conducts regular programming classes, organizes national and regional contests, hosts IT fests, project exhibitions, and seminars, and facilitates research publications. With dedicated student-led groups in IoT, Embedded Systems, Deep Neural Research, DevOps, Linux-Based Networking, and Mobile/Game Development, the club promotes hands-on learning and collaboration. Through these initiatives, it enhances the campus’s technological ecosystem and prepares students for industry challenges. The IEEE Student Branch arranges seminars, workshops, trainings, talks, etc., on cutting-edge technologies related to computer science and related disciplines.

Alumni of the department of CSE are its greatest asset since they offer a positive perception rating to the department by being among its most distinguished. The Computer Science and Engineering Alumni Association, PU (CSEAA_PU) formed on 14th April 2023 is now operating effectively. The CSE department has expanded over the years with proud Alumni working leading corporations both domestically and internationally. Many graduates are working as professors and continuing their education abroad. Our way of thinking and operating will change as a result of the Fourth Industrial Revolution (4IR). 4IR integrates use of advancements in Big Data, Machine Learning, Artificial Intelligence (AI), the Internet of Things (IoT), Blockchain, and other technologies.